Green Analytical Chemistry In Pharmaceutical Analysis

Abstract

Green analytical chemistry has emerged as a transformative paradigm in pharmaceutical analysis, addressing critical environmental and health concerns associated with conventional analytical methods. The primary objective of this study was to evaluate the implementation of green analytical chemistry principles in pharmaceutical analysis by examining green solvents, assessment metrics, and chromatographic techniques. Employing a comprehensive review methodology, this research analyzed various green analytical approaches including supercritical fluid chromatography, ultra-high-performance liquid chromatography, and green solvent systems. The hypothesis posited that green analytical methods would demonstrate comparable analytical performance while significantly reducing environmental impact. Results revealed substantial improvements in environmental sustainability metrics, with analytical eco-scale scores ranging from 85-91, AGREE scores between 0.75-0.91, and significant reductions in organic solvent consumption. Green solvents such as ethanol, water, and supercritical carbon dioxide demonstrated excellent analytical performance with reduced toxicity profiles. Discussion highlights the successful integration of green chemistry principles through miniaturization, solvent replacement, and energy-efficient techniques. This research concludes that green analytical chemistry represents a viable, environmentally responsible approach for pharmaceutical analysis without compromising analytical quality, supporting sustainable development goals in the pharmaceutical industry.